Retinoblastoma protein antibody (10R-8455)

Mouse monoclonal Retinoblastoma protein antibody

Synonyms Monoclonal Retinoblastoma protein antibody, Anti-Retinoblastoma protein antibody, RB1 antibody, retinoblastoma 1 antibody, BOS_12359 antibody, OSRC antibody, p104 antibody, P105-RB antibody, pp105 antibody, PP110 antibody, pRb antibody, Rb antibody, Rb-1 antibody, RB11 antibody, retinoblastoma antibody, Retinoblastoma 1 (including osteosarcoma) antibody, retinoblastoma-associated protein antibody, retinoblastoma protein antibody, retinoblastoma protein 1 antibody, retinoblastoma antibody, susceptibility antibody, retinoblastoma suspectibility protein antibody, RP11-174I10.1 antibody
Cross Reactivity Human
Applications ELISA, IP, WB
Immunogen Retinoblastoma protein antibody was raised in Mouse using a recombinant human protein purified from E.coli as the immunogen

Images

Western Blot analysis using Retinoblastoma protein antibody (10R-8455)

Specifications

Host Mouse
Clone 7E6
Isotype IgG1 kappa
Method of Purification Retinoblastoma protein antibody was purified by ammonium sulfate precipitation
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:2000, IP: 1 ul

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance The Rb protein (pRb, 110 kDa) is a tumor suppressor, which plays a pivotal role in the negative control of the cell cycle and in tumor progression. pRb is responsible for a major G1 checkpoint, blocking S-phase entry and cell growth. pRb prevents the cell from replicating damaged DNA by preventing its progression through the cell cycle into its S phase or progressing through G1 phase. pRb can actively inhibit cell cycle progression when it is dephosphorylated while this function is inactivated when pRb is phosphorylated. pRb is activated near the end of mitosis (M phase) when a phosphatase dephosphorylates it, allowing it to bind E2F. The pRb protein represses gene transcription, required for transition from G1 to S phase, by directly binding to the transactivation domain of E2F and by binding to the promoter of these genes as a complex with E2F.

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Images

  • Western Blot analysis using Retinoblastoma protein antibody (10R-8455) |

Availability: In stock

Price: $295.00
Size: 100 ul
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