RIP2 antibody (10R-8570)

Mouse monoclonal RIP2 antibody

Synonyms Monoclonal RIP2 antibody, Anti-RIP2 antibody, RIPK2 antibody, receptor-interacting serine-threonine kinase 2 antibody, BOS_14104 antibody, CARD3 antibody, CARD-carrying kinase antibody, CARD-containing IL-1 beta ICE-kinase antibody, CARD-containing interleukin-1 beta-converting enzyme-associated kinase antibody, CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase antibody, CARDIAK antibody, CCK antibody, D4Bwg0615e antibody, GIG30 antibody, growth-inhibiting gene 30 antibody, PANDA_012473 antibody, RCJMB04_15n4 antibody, receptor interacting protein 2 antibody, receptor-interacting protein 2 antibody, receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase antibody, receptor-interacting serine/threonine-protein kinase 2 antibody, receptor (TNFRSF)-interacting serine-threonine kinase 2 antibody, RICK antibody, RIP2 antibody, RIP-2 antibody, RIP-like-interacting CLARP kinase antibody, RP23-378L22.1 antibody, tyrosine-protein kinase RIPK2 antibody, WUGSC:H_RG437L15.1 antibody
Cross Reactivity Human, Mouse, Rat
Applications ELISA, IP, WB
Immunogen RIP2 antibody was raised in Mouse using a recombinant human protein purified from E.coli (His-RIP2) as the immunogen

Images

Western Blot analysis using RIP2 antibody (10R-8570)

Specifications

Host Mouse
Clone AF28D3
Isotype IgG1 kappa
Method of Purification RIP2 antibody was purified by ammonium sulfate precipitation
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:2000, IP: 3 ul

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance The RIP (receptor-interacting protein) family of serine/Threonine kinases (RIP-1,2,3,4,5,6,7) are crucial regulators of cell survival and cell death that can trigger pro-survival, inflammatory and immune responses via the activation of transcription factors (NF-kB and AP-1) and death-inducing programs. RIP2 (also known as RICK, CARDIAK, CCK and Ripk2) transduces signals from receptors of both immune responses. RIP2 carries a CARD at its C-terminal, which is essential for NF-kB activation. RIP2 is a critical downstream mediator of Nod1 and Nod2 signaling. Overexpression of RIP2 results in the activation of, in addition to NF-kB, the MAPKs JNK and ERK2, requiring its kinase activity to activate ERK2, but not JNK.

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Images

  • Western Blot analysis using RIP2 antibody (10R-8570) |

Availability: In stock

Price: $295.00
Size: 100 ul
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