RNASEH2A protein (His tag) (80R-2843)

Purified recombinant RNASEH2A protein (His tag)

Synonyms RNASEH2A, RNASEH 2A, RNASEH-2A, RNASEH2A, RNASEH 2A protein, RNASEH-2A protein, Ribonuclease H2 subunit A protein, AGS4 protein, JUNB protein, RNASEHI protein, RNHIA protein, RNHL protein
Species Human
Protein Type Recombinant
Applications SDS-PAGE

Images

SDS-PAGE analysis of RNASEH2A protein (His tag) (80R-2843)

Figure annotation denotes ug of protein loaded and % gel used.

Specifications

Residues 1-299 aa: MGSSHHHHHH SSGLVPRGSH MGSMDLSELE RDNTGRCRLS SPVPAVCRKE PCVLGVDEAG RGPVLGPMVY AICYCPLPRL ADLEALKVAD SKTLLESERE RLFAKMEDTD FVGWALDVLS PNLISTSMLG RVKYNLNSLS HDTATGLIQY ALDQGVNVTQ VFVDTVGMPE TYQARLQQSF PGIEVTVKAK ADALYPVVSA ASICAKVARD QAVKKWQFVE KLQDLDTDYG SGYPNDPKTK AWLKEHVEPV FGFPQFVRFS WRTAQTILEK EAEDVIWEDS ASENQEGLRK ITSYFLNEGS QARPRSSHRY FLERGLESAT SL
Expression System E.coli
Purity > 85% pure
Molecular Weight 35.8 kDa
Tag/Conjugate His tag
Form & Buffer Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol

Storage & Safety

Storage Can be stored at 4 deg C short term (1-2 weeks). For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freezing and thawing cycles.

General Information

Biological Significance Ribonuclease H2 subunit A, also known as RNASEH2A, belongs to the RNase HII family and eukaryotic subfamily. Localized to the nucleus, RNASEH2A mediates the removal of Okazaki fragment RNA primers that are present on the lagging strand during DNA replication. RNASEH2A catalyzes the endonucleolytic cleavage of RNA to a 5’-phosphomonoester and is able to bind magnesium or manganese as cofactors. Defects in RNASEH2A are the cause of Aicardi-Goutieres syndrome type 4 (AGS4). Recombinant human RNASEH2A protein, fused to His-tag at N-terminus, was expressed in E.coli

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Images

  • SDS-PAGE analysis of RNASEH2A protein (His tag) (80R-2843) | Figure annotation denotes ug of protein loaded and % gel used.

Availability: In stock

Price: $365.00
Size: 100 ug
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