RNF34 protein (His tag) (80R-3552)
Purified recombinant RNF34 protein (His tag)
|Synonyms||CARP-1 protein, CARP1 protein, Caspase regulator CARP1 protein, Caspases-8 and-10-associated RING finger protein 1 protein, E3 ubiquitin-protein ligase protein, ring finger protein 34 protein, FLJ21786 protein, RIF protein, RIFF protein, E3 ubiquitin protein ligase RNF34 isoform 1 protein, RNF 34 protein, RNF-34 protein|
Coomassie blue stained SDS-PAGE of RNF34 protein (His tag) (80R-3552)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-373 aa: MGSSHHHHHH SSGLVPRGSH MGSMRKAGAT SMWASCCGLL NEVMGTGAVR GQQSAFAGAT GPFRFTPNPE FSTYPPAATE GPNIVCKACGLSFSVFRKKH VCCDCKKDFC SVCSVLQENL RRCSTCHLLQ ETAFQRPQLM RLKVKDLRQY LILRNIPIDT CREKEDLVDL VLCHHGLGSEDDMDTSSLNS SRSQTSSFFT RSFFSNYTAP SATMSSFQGE LMDGDQTSRS GVPAQVQSEI TSANTEDDDD DDDEDDDDEE ENAEDRNPGLSKERVRASLS DLSSLDDVEG MSVRQLKEIL ARNFVNYSGC CEKWELVEKV NRLYKENEEN QKSYGERLQL QDEEDDSLCR ICMDAVIDCVLLECGHMVTC TKCGKRMSEC PICRQYVVRA VHVFKS|
|Purity||> 90% pure|
|Method of Purification||RNF34 protein was purified by using conventional chromatography techniques|
|Molecular Weight||44.2 kDa|
|Form & Buffer||Supplied in liquid form in 20 mM Tris-HCl buffer (pH8.0) containing 10% glycerol 0.1M NaCl, 1mM DTT|
Storage & Safety
|Storage||Can be stored at 4 deg C short term (1-2 weeks). For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freezing and thawing cycles.|
|Biological Significance||RNF34contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms.|
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