ROCK2 antibody (20R-2903)

Rabbit polyclonal ROCK2 antibody

Synonyms Polyclonal ROCK2 antibody, Anti-ROCK2 antibody, ROCK2 antibody, Rho-associated antibody, coiled-coil containing protein kinase 2 antibody, BOS_11805 antibody, p150 ROK-alpha antibody, p164 ROCK-2 antibody, rhoA-binding kinase 2 antibody, RhoA - binding serine/threosine kinase alpha (ROK - alpha) antibody, rho-associated antibody, coiled-coil-containing protein kinase 2 antibody, Rho-associated coiled-coil containing protein kinase 2 antibody, rho-associated antibody, coiled-coil-containing protein kinase II antibody, Rho-associated coiled-coil forming kinage 2 antibody, Rho-associated coiled-coil forming kinase 2 antibody, Rho-associated kinase alpha antibody, rho-associated protein kinase 2 antibody, Rho-kinase antibody, Rho-kinase alpha antibody, Rock2m antibody, rocka-a antibody, Rock-II antibody, ROK antibody, ROKalpha antibody, xROK antibody
Cross Reactivity Human, Mouse, Rat
Applications IHC, WB
Immunogen ROCK2 antibody was raised in Rabbit using a synthetic target peptide as the immunogen

Images

Western Blot analysis using ROCK2 antibody (20R-2903)

Specifications

Host Rabbit
Isotype IgG
Method of Purification ROCK2 antibody was purified by Protein A affinity chromatography
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:2000

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance ROCK, Rho-associated coiled-coil forming kinases, is a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. ROCK, as a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. ROCK2 regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element.

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Images

  • Western Blot analysis using ROCK2 antibody (20R-2903) |

Availability: In stock

Price: $295.00
Size: 100 ul
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