RXRalpha protein (30R-1037)
Purified recombinant Human RXRalpha protein
|Synonyms||RXR-alpha protein, Nuclear receptor subfamily 2 group B member 1 protein, RXRA protein, RXRalpha1 protein, NR2B1 protein, Retinoid X receptor alpha protein, MGC102720 protein, Retinoic acid receptor RXR alpha protein, Retinoid x receptor protein, RXRA1, RXR alpha1 protein, FLJ16020 protein, Retinoic acid receptor RXR-alpha protein, FLJ16733 protein|
Coomassie Blue stained SDS-PAGE of RXRalpha protein (30R-1037)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||111-228 amino acids: MLGLNGVLKV PAHPSGNMAS FTKHICAICG DRSSGKHYGV YSCEGCKGFF KRTVRKDLTY TCRDNKDCLI DKRQRNRCQY CRYQKCLAMG MKREAVQEER QRGKDRNENE VESTSSANE|
|Purity||> 95% pure|
|Molecular Weight||13.6 kDa (119 aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl, pH7.5, containing 0.1M NaCl, and 5mM beta-Mercaptoethanol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||The retinoid X receptor (RXR) is a pleiotropic nuclear receptor transcription factor that interacts with a variety of nuclear receptor dimeric partner. RXR binds cognate response elements as a homodimer in the presence of its ligand, 9-cis retinoic acid, or as a heterodimer with other members of the nuclear hormone receptor superfamily including retinoic acid receptors (RAR), thyroid hormone receptors (TR), vitamin D receptors and peroxisome proliferators-activated receptors (PPAR). The RXR family includes three difference isoforms; RXR alpha, beta, gamma. Human RXR alpha gene is localized on 9q34.9 and encodes two major isoforms (RXR alpha1, RXR alpha2). The DNA binding domain of RXR (111-228aa) was over expressed in E. coli and purified by using conventional column chromatography techniques.|
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