SAP18 protein (His tag) (80R-1162)
Purified recombinant Human SAP18 protein
|Synonyms||SAP18, SAP 18 protein, SAP-18 protein, Sin3A-associated protein protein, 18kDa Histone deacetylase complex subunit SAP18 protein, 2HOR0202 protein, SAP-18, SAP 18, SAP18 protein, SAP18P protein, Sin3-associated polypeptide p18., Sin3A-associated protein protein|
Coomassie Blue stained SDS-PAGE of SAP18 protein (His tag) (80R-1162)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||20-172 amino acids: MGSSHHHHHH SSGLVPRGSH MAVESRVTQE EIKKEPEKPI DREKTCPLLL RVFTTNNGRH HRMDEFSRGN VPSSELQIYT WMDATLKELT SLVKEVYPEA RKKGTHFNFA IVFTDVKRPG YRVKEIGSTM SGRKGTDDSM TLQSQKFQIG DYLDIAITPP NRAPPPSGRM RPY|
|Purity||> 90% pure|
|Molecular Weight||19.7 kDa (173 aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 0.1M NaCl, 30% glycerol, and 1mM DTT.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Endotoxin Levels||< 1.0 EU per ug of protein (determined by LAL method)|
|Biological Significance||SAP18, also known as Sin3A-associated protein, is component of the histone deacetylase complex that plays an important role in the regulation of eukaryotic gene expression. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. It also has been shown to play a key role in gene-specific recruitment of the HDAC complex by a number of transcription factors including Gli, GAGA, and Bicoid. Recombinant SAP18 protein was expressed in E. coli and purified by using conventional chromatography techniques.|
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