SCL70 protein (30-1294)

Purified recombinant SCL70 protein

Synonyms SCL70, SCL 70 protein, SCL-70 protein, Scleroderma protein
Species Human
Protein Type Recombinant
Applications ELISA, Immunoassays, WB

Specifications

Expression System E.coli
Form & Buffer Supplied in PBS buffer with 500 mM NaCl

Usage & Assay Information

Usage Recommendations To be optimized by the end user

Storage & Safety

Storage Store at 4 deg C for short term storage, aliquot and freeze at -20 deg C for long term storage

General Information

Biological Significance SCL70 is an antigen present on topoisomerase I, which is an ubiquitous intranuclear enzyme that mediates the twisting and untwisting of the DNA helix during gene transcription. It is a basic nuclear protein with a molecular weight of 70,000 daltons. Antibodies directed against Scl-70 usually give a nucleolar ANA pattern and are present exclusively in 70% of patients with severe, diffuse forms of progressive systemic sclerosis, also known as scleroderma.

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Availability: In stock

Price: $1,195.00
Size: 1 mg
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