SEC61B protein (His tag) (80R-3587)
Purified recombinant SEC61B protein (His tag)
|Synonyms||Sec61 beta subunit protein, SEC6 1B protein, SEC6-1B protein|
Coomassie blue stained SDS-PAGE of SEC61B protein (His tag) (80R-3587)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-70 aa: MGSSHHHHHH SSGLVPRGSH MGSMPGPTPS GTNVGSSGRS PSKAVAARAA GSTVRQRKNA SCGTRSAGRT TSAGTGGMWR FYTEDSPGLK VGP|
|Purity||> 85% pure|
|Method of Purification||SEC61B protein was purified by using conventional chromatography techniques|
|Molecular Weight||9.4 kDa|
|Form & Buffer||Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 50% glycerol, 2mM DTT|
Storage & Safety
|Storage||Can be stored at 4 deg C short term (1-2 weeks). For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freezing and thawing cycles.|
|Biological Significance||The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript.|
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