Shc1 antibody (10R-8484)

Mouse monoclonal Shc1 antibody

Synonyms Monoclonal Shc1 antibody, Anti-Shc1 antibody, SHC1 antibody, SHC (Src homology 2 domain containing) transforming protein 1 antibody, adaptor protein SHC antibody, BOS_2793 antibody, p60Shc antibody, p66 antibody, p66shc antibody, RP11-307C12.1 antibody, SH2 domain protein C1 antibody, shc antibody, ShcA antibody, SHC (Src homology 2 domain-containing) transforming protein 1 antibody, SHC-transforming protein 1 antibody, SHC-transforming protein 3 antibody, SHC-transforming protein A antibody, src homology 2 domain-containing transforming protein C1 antibody, src homology 2 domain-containing-transforming protein C1 antibody, src homology collagen antibody
Cross Reactivity Human, Mouse, Rat
Applications ELISA, IP, WB
Immunogen Shc1 antibody was raised in Mouse using a recombinant human protein purified from E.coli (His/ABD-Shc1) as the immunogen

Images

Western Blot analysis using Shc1 antibody (10R-8484)

Specifications

Host Mouse
Clone 47F4
Isotype IgG1 kappa
Method of Purification Shc1 antibody was purified by ammonium sulfate precipitation
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1: 5000, IP: 1 ul

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance Shc1 is a prototype adapter protein that is expressed from the earliest stages of T-cell development. Shc becomes rapidly tyrosine phosphorylated after T-cell receptor (TCR) engagement. Three shc genes have been identified in mammals and their gene products have been referred to as ShcA, ShcB and ShcC. ShcA is ubiquitously expressed, while shcB and ShcC expression appear limited to neuronal cells. ShcA is expressed as three isoforms of about 46, 52 and 66 kDa. Shc is composed of an N-terminal PTB, a central collagen-homology (CH) domain and a C-terminal SH2 domain. The 66 kDa isoform of ShcA is expressed in most cells except in the hematopoietic lineage and contains an additional amino-terminal CH-like region.

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Images

  • Western Blot analysis using Shc1 antibody (10R-8484) |

Availability: In stock

Price: $295.00
Size: 100 ul
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