SHP2 antibody (10R-8469)

Mouse monoclonal SHP2 antibody

Synonyms Monoclonal SHP2 antibody, Anti-SHP2 antibody, PTPN11 antibody, protein tyrosine phosphatase antibody, non-receptor type 11 antibody, BOS_16688 antibody, BPTP3 antibody, CFC antibody, cSH-PTP2 antibody, encodes catalytic domain antibody, non-receptor type protein tyrosine phosphatase SHP2 antibody, NS1 antibody, null antibody, phosphotyrosyl-protein phosphatase antibody, protein-tyrosine phosphatase 1D antibody, protein-tyrosine phosphatase 2C antibody, protein tyrosine phosphatase antibody, non-receptor type 11 (Noonan syndrome 1) antibody, protein tyrosine phosphatase SH-PTP2 antibody, protein-tyrosine phosphatase SYP antibody, PTP1D antibody, PTP-1D antibody, ptp-2 antibody, PTP2C antibody, PTP-2C antibody, SAP-2 antibody, SH2 domain-containing protein tyrosine phosphatase-2 antibody, Shp2 antibody, SHP-2 antibody, SH-PTP2 antibody, SH-PTP2 protein tyrosine phosphatase non-receptor type 11 antibody, SH-PTP2 protein tyrosine phosphatase antibody, non-receptor type 11 antibody, SH-PTP3 antibody, SYP antibody, tyrosine-protein phosphatase non-receptor type 11 antibody
Cross Reactivity Human, Mouse, Rat
Applications IP, WB
Immunogen SHP2 antibody was raised in Mouse using a recombinant human GST-SHP2 protein purified from E.coli as the immunogen

Images

Western Blot analysis using SHP2 antibody (10R-8469)

Specifications

Host Mouse
Clone 5F2
Isotype IgG1 kappa
Method of Purification SHP2 antibody was purified by ammonium sulfate precipitation
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:2000, IP: 1 ul

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance SHP2 is a tyrosine phosphatase containing two tandem SH2 (src homology 2) domains. Protein tyrosine phosphatases (PTPs) are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins. Together with tyrosine kinases, PTPs regulate the phosphorylation state of many important signaling molecules. SHP1 and SHP2 represent a subfamily of non-transmembrane PTPs that contain two SH2 domains followed by a PTP domain. Tyrosine phosphorylation of SHP2 is required for normal ERK activation in response to some growth factors. In the inactive state, the N-terminal SH2 domain binds the PTP domain and blocks access of potential substrates to the active site. This auto-inhibition is relieved by the binding of phosphopeptides to SH2 domain, resulting in activation of phostphatase activity.

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Images

  • Western Blot analysis using SHP2 antibody (10R-8469) |

Availability: In stock

Price: $295.00
Size: 100 ul
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