SIV mac251 p28 antibody (HRP) (61-002202)

Mouse monoclonal SIV mac251 gp120 antibody (HRP)

Synonyms Monoclonal SIV mac251 gp28 antibody, Anti-SIV mac251 gp28 antibody, SIV mac25 p28 1, SU antibody, gp28 glycoprotein antibody, SIV mac25 p28-1, SIV mac25 p28-1 antibody, SIV1 mac251 p28, Surface protein antibody, SIV mac25 p28 1 antibody, gp28 antibody, Simian Immunodeficiency Virus 1 antibody, Glycoprotein 28 antibody, Envelope surface glycoprotein gp28 antibody, gp28 antibody
Specificity SIV1 mac251 p28
Applications ELISA, WB
Immunogen SIV mac251 p28 antibody was raised in mouse using SIV mac251 p28 as the immunogen.
Assay Information Binds to recombinant p28 (SIV mac251), not epitope mapped.

Specifications

Host Mouse
Clone 3F7
Isotype IgG1
Tag/Conjugate HRP
Form & Buffer Supplied as a purified IgG in 50mM Tris buffer, pH 8.0, with no preservatives added. The HRP is attached by glutaraldehyde coupling to the lysine residue.
Concentration 50 ug/vial

Usage & Assay Information

Usage Recommendations ELISA: 1:1000, WB: 1:500-1:1000

Storage & Safety

Storage Store lyophilized product at 2-8 deg C short term, following reconstitution, aliquot and store at -70 deg C or lower. Avoid repeated freeze/thaw cycles
Biohazard Information Not tested for sterility or endotoxin content.

General Information

Biological Significance HIV1 is equipped with the envelope gp160 glycoprotein for interaction with Langerhans cells and dendritic cells, which confront the virus at the portal of virus entry in the human body. These cells are equipped with receptors by which they bind and endocytose the virus. The gp120 glycoprotein is used for binding to CD4 receptor and CCR5 co-receptor of T helper 2 (Th2) cells, and is able to induce FcepsilonRI(+) hematopoietic cells to produce IL4. This inactivates the host adaptive immune response.

References
Add a Paper

Campbell JH, Ratai EM, Autissier P, Nolan DJ, Tse S, Miller AD, González RG, Salemi M, Burdo TH, Williams KC

Anti-α4 Antibody Treatment Blocks Virus Traffic to the Brain and Gut Early, and Stabilizes CNS Injury Late in Infection

Plos Pathogens

Volume: 10 Issue: 12 PMID: 25502752 DOI: 10.1371/journal.ppat.1004533

Brian T. Nowlin, Tricia H. Burdo, Cecily C. Midkiff, Marco Salemi, Xavier Alvarez, Kenneth C. Williams

SIV Encephalitis Lesions Are Composed of CD163+ Macrophages Present in the Central Nervous System during Early SIV Infection and SIV-Positive Macrophages Recruited Terminally with AIDS

The American Journal of Pathology

DOI: 10.1016/j.ajpath.2015.01.033

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Availability: In stock

Price: $295.00
Size: 50 ug
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