SIVA1 protein (His tag) (80R-3493)
Purified recombinant SIVA1 protein (His tag)
|Synonyms||CD27BP protein, SIVA protein, Siva-1 protein, Siva-2 protein, SIVA 1 protein|
Coomassie blue stained SDS-PAGE of SIVA1 protein (His tag) (80R-3493)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-175 aa: MGSSHHHHHH SSGLVPRGSH MGSMPKRSCP FADVAPLQLK VRVSQRELSR GVCAERYSQE VFEKTKRLLF LGAQAYLDHV WDEGCAVVHLPESPKPGPTG APRAARGQML IGPDGRLIRS LGQASEADPS GVASIACSSC VRAVDGKAVC GQCERALCGQ CVRTCWGCGS VACTLCGLVD CSDMYEKVLC TSCAMFET|
|Purity||> 85% pure|
|Method of Purification||SIVA1 protein was purified by using conventional chromatography techniques|
|Molecular Weight||21.1 kDa|
|Form & Buffer||Supplied in liquid form in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M urea|
Storage & Safety
|Storage||Can be stored at 4 deg C short term (1-2 weeks). For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freezing and thawing cycles.|
|Biological Significance||Apoptosis regulatory protein Siva isoform 1, also known as SIVA1, is a death domain-containing proapoptotic protein identified as an intracellular ligand of CD27 and of the glucocorticoid-induced TNFR family-related gene, which are two members of the TNFR family expressed on lymphoid cells. SIVA1 expression is up-regulated in multiple pathological processes, little is known about the signaling pathway underlying the Siva-induced apoptosis.|
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