SLD5 antibody (10R-1768)

Rat monoclonal SLD5 antibody

Synonyms Monoclonal SLD5 antibody, Anti-SLD5 antibody, SLD5 antibody, SLD-5 antibody, GINS complex subunit 4 antibody, GINS4 antibody, SLD5, SLD 5, SLD-5, SLD 5 antibody, SLD-5 antibody
Specificity Human and Mouse SLD5
Applications ICC, IHC, WB
Immunogen SLD5 antibody was raised in rats which were immunized with murine SLD5. Rat spleen cells were isolated and fused with mouse melanoma in order to establish hybridoma cells.

Specifications

Host Rat
Clone ASF3-3-4
Isotype IgG
Method of Purification SLD5 antibody was purified by protein G chromatography
Form & Buffer Supplied in liquid form, containing PBS and 0.09% NaN3.
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations Optimal conditions to be determined by end user

Storage & Safety

Storage Aliquot and store at -20 deg C. Avoid repeated freeze-thawing.

General Information

Biological Significance The GINS complex is composed of four subunits, encoded by SLD5, PSF1, PSF2, and PSF3. Genetic interactions between these four genes also suggest that they act together . The GINS complex was independently isolated in a large scale screen for cell cycle defects. A similar complex is found in Xenopus and has a ring-like structure . Cells defective in SLD5, PSF1, or PSF2 are impaired in their ability to replicate DNA. The complex localizes to origins of DNA replication and Sld5p was previously implicated as functioning in DNA replication due to its genetic interaction with DPB11. Additional genetic and biochemical interactions of the GINS complex with Dpb11p, Dpb2p, and Sld3p suggest that it functions in some way at the replication fork during DNA synthesis.

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Availability: In stock

Price: $395.00
Size: 50 ug
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