SMAD4 antibody (10R-1570)

Mouse monoclonal SMAD4 antibody

Synonyms Monoclonal SMAD4 antibody, Anti-SMAD4 antibody, SMAD 4, SMAD-4, MADH4 antibody, JIP antibody, SMAD4, SMAD-4 antibody, SMAD family member 4 antibody, SMAD 4 antibody, DPC4 antibody
Specificity Human SMAD4
Cross Reactivity Human. Other species not studied
Applications Dot Blot
Immunogen SMAD4 antibody was raised in mouse using recombinant Human Smad Family Member 4 (Smad4)

Images

Western Blot analysis of immunized recombinant protein using SMAD4 antibody (10R-1570)

Specifications

Host Mouse
Clone 188C1a
Isotype IgG1
Method of Purification SMAD4 antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Form & Buffer SMAD4 antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3 ).
Concentration 100 ug/ml

Usage & Assay Information

Usage Recommendations To be optimized by the end user.

Storage & Safety

Storage Store at 2-8 deg C for up to one year. We recommend long term storage at -20 deg C. Avoid repeated freezing and thawing.
Biohazard Information This antibody solution contains sodium azide (NaN ) as a preservative. There is a potential hazard that NaN reacts with copper or lead to produce an explosive compound. For safe disposal, the vial has to be washed thoroughly with water. It is strongly adv

General Information

Biological Significance This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8 bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.

References
Add a Paper

Sorry, but there are no references currently for this product.

Reviews

You need to be logged in to write a review. Please login here

Sorry there are currently no reviews for this product

Images

  • Western Blot analysis of immunized recombinant protein using SMAD4 antibody (10R-1570)

Availability: In stock

Price: $190.00
Size: 50 ug
OR
Shipping
View Our Distributors