SMC1 antibody (10R-2208)

Mouse monoclonal SMC1 antibody

Synonyms Monoclonal SMC1 antibody, Anti-SMC1 antibody, SM-1c antibody, SM 1c antibody, Structural maintenance of chromosomes 1A antibody, SMC protein 1A antibody, SM-1c-alpha antibody, SMC1, SM 1c, SM-1c, SM 1c antibody, SM-1c antibody
Cross Reactivity Human
Applications ELISA, IF, IHC, WB
Immunogen SMC1 antibody was raised in Mouse using a purified recombinant fragment of human SMC1 expressed in E. coli as the immunogen.

Images

Flow Cytometric assay using Western Blot analysis using SMC1 antibody (10R-2208) (SMC1 antibody)

FC analysis of Hela cells using SMC1 antibody (green) and negative control (purple).

Specifications

Host Mouse
Clone 5B6
Isotype IgG1
Form & Buffer Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.
Concentration 1.0 mg/ml

Usage & Assay Information

Usage Recommendations ELISA: 1:10,000, IF: 1:200-1:1000, IHC: 1:200-1:1000, WB: 1:200-1:1000

Storage & Safety

Storage Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair.

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Images

  • Flow Cytometric assay using Western Blot analysis using SMC1 antibody (10R-2208) (SMC1 antibody) | FC analysis of Hela cells using SMC1 antibody (green) and negative control (purple).
  • Western Blot analysis using SMC1 antibody (10R-2208) | Western Blot showing SMC1 antibody used against K562 (1), Jurkat (2) and A549 (3) cell lysate.
  • Immunohistochemical staining using SMC1 antibody (10R-2208) | Immunohistochemical analysis of paraffin-embedded human colon using SMC1 antibody with DAB staining.
  • Immunofluorescent staining using Western Blot analysis using SMC1 antibody (10R-2208) (SMC1 antibody) | Immunofluorescence analysis of NIH/3T3 cells using SMC1 antibody (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.

Availability: In stock

Price: $345.00
Size: 100 ul
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