SNUPN protein (His tag) (80R-1402)
Purified recombinant Human SNUPN protein
|Synonyms||SPN1 protein, Snurportin1 protein, Snurportin1, RNUT1 protein, KPNBL protein|
Coomassie Blue stained SDS-PAGE of SNUPN protein (His tag) (80R-1402)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-360 amino acids: MGSSHHHHHH SSGLVPRGSH MEELSQALAS SFSVSQDLNS TAAPHPRLSQ YKSKYSSLEQ SERRRRLLEL QKSKRLDYVN HARRLAEDDW TGMESEEENK KDDEEMDIDT VKKLPKHYAN QLMLSEWLID VPSDLGQEWI VVVCPVGKRA LIVASRGSTS AYTKSGYCVN RFSSLLPGGN RRNSTAKDYT ILDCIYNEVN QTYYVLDVMC WRGHPFYDCQ TDFRFYWMHS KLPEEEGLGE KTKLNPFKFV GLKNFPCTPE SLCDVLSMDF PFEVDGLLFY HKQTHYSPGS TPLVGWLRPY MVSDVLGVAV PAGPLTTKPD YAGHQLQQIM EHKKSQKEGM KEKLTHKASE NGHYELEHLS TPKLKGSSHS PDHPGCLMEN|
|Purity||> 90% pure|
|Molecular Weight||43.3 (380aa) confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol and 0.1M NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||SNUPN, also known as KPNBL or RNUT1, is a nuclear import adaptor protein belonging to the Snurportin family. Localizing to the cytoplasm and nucleus, Snurportin-1 contains an N-terminal IBB domain and a trimethylguanosine (m3G)-cap binding domain. It specifically binds the terminal 2,2,7-m3G-cap at the 5' end of U snRNPs and functions to transport U snRNPs into the nucleus via an association with Importin ?. Recombinant human Snurportin-1 protien, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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