SORL1 antibody (10R-2112)

Mouse monoclonal SORL1 antibody

Synonyms Monoclonal SORL1 antibody, Anti-SORL1 antibody, Sortilin related receptor L A repeats containing antibody, SORL1, SORL 1, SORL-1, SORL 1 antibody, SORL-1 antibody
Cross Reactivity Human
Applications ELISA, IF, IHC, WB
Immunogen SORL1 antibody was raised in Mouse using a purified recombinant fragment of human SORL1 expressed in E. coli as the immunogen.

Images

Immunofluorescent staining using Western Blot analysis using SORL1 antibody (10R-2112) (SORL1 antibody)

Confocal immunofluorescence analysis of PANC-1 cells using SORL1 antibody (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. Blue: DRAQ5 fluorescent DNA dye.

Specifications

Host Mouse
Clone 3B6B11
Isotype IgG1
Form & Buffer Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.
Concentration 1.0 mg/ml

Usage & Assay Information

Usage Recommendations ELISA: 1:10,000, IF: 1:200-1:1000, IHC: 1:200-1:1000, WB: 1:500-1:2000

Storage & Safety

Storage Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance SORL1 is a Type I membrane protein that may be involved in cell-cell interaction. SorLA, a single transmembrane receptor, binds LDL and transports it into cells by endocytosis. SorLA is synthesized as a proreceptor which is processed to the mature form by a furin-like propeptidase. It can also bind to RAP (receptor-associated protein). SorLA is a multifunctional endocytis receptor important in lipoprotein and protease uptake. The N-terminal propeptide, which is removed, can be cleaved by furin or homologous proteases. Endogenous SorLA binds the neuropeptide head activator (HA) and is important for HA signaling and function.

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Images

  • Immunofluorescent staining using Western Blot analysis using SORL1 antibody (10R-2112) (SORL1 antibody) | Confocal immunofluorescence analysis of PANC-1 cells using SORL1 antibody (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. Blue: DRAQ5 fluorescent DNA dye.
  • Western Blot analysis using SORL1 antibody (10R-2112) | Western Blot showing SORL1 antibody used against truncated SORL1 recombinant protein.
  • Immunohistochemical staining using SORL1 antibody (10R-2112) | Immunohistochemical analysis of paraffin-embedded human brain, cortex tissues using SORL1 antibody.
  • Immunohistochemical staining using SORL1 antibody (10R-2112) | Immunohistochemical analysis of paraffin-embedded human cerebrum tissues using SORL1 antibody with DAB staining.

Availability: In stock

Price: $345.00
Size: 100 ul
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