SOS1 antibody (10R-8598)

Mouse monoclonal SOS1 antibody

Synonyms Monoclonal SOS1 antibody, Anti-SOS1 antibody, SOS1 antibody, son of sevenless homolog 1 (Drosophila) antibody, 9630010N06 antibody, BOS_11522 antibody, fj59e07 antibody, GF1 antibody, GGF1 antibody, GINGF antibody, gingival fibromatosis antibody, hereditary antibody, 1 antibody, guanine nucleotide exchange factor antibody, guanine nucleotide releasing factor antibody, HGF antibody, NS4 antibody, PANDA_013349 antibody, ras guanine exchange factor antibody, son-of-sevenless 1 antibody, son of sevenless homolog antibody, Son of sevenless homolog 1 antibody, SOS-1 antibody
Cross Reactivity Human, Mouse, Rat
Applications ELISA, WB
Immunogen SOS1 antibody was raised in Mouse using a recombinant human protein purified from E.coli (His/ABD-SOS1) as the immunogen

Images

Western Blot analysis using SOS1 antibody (10R-8598)

Specifications

Host Mouse
Clone AF3F11
Isotype IgG1 kappa
Method of Purification SOS1 antibody was purified by ammonium sulfate precipitation
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:1000

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance Son of sevenless (SOS) is a guanine nucleotide exchange factor that activates Ras in response to growth factor stimulation. Sos1, and itsclosely related Sos2 paralog, are comprised of an N-terminal histone-binding domain, a Rac GEF catalytic (DH) domain juxtaposed with a PH domain, a Ras exchanger motif (REM) domain, a Ras GEF catalytic domain, and a C-terminal proline-rich region. Sos1 catalyzes the GDP-GTP exchange within the membrane-bound GTPase Ras andthereby switches on a key signaling circuit that involves the activation of MAPK cascade central to cellular proliferation, survival and differentiation. Growth factor stimulation rapidly induces the phosphorylation of Sos on multiple serine and threonine sites.

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Images

  • Western Blot analysis using SOS1 antibody (10R-8598) |

Availability: In stock

Price: $295.00
Size: 100 ul
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