SPG21 protein (His tag) (80R-1128)
Purified recombinant Human SPG21 protein
|Synonyms||Spastic paraplegia 21 isoform a Acid cluster protein 33 protein, GL010 protein, SPG 21, ACP33 protein, SPG21, BM019 protein, SPG-21 protein, SPG 21 protein, SPG-21, Maspardin protein, MAST protein, Spastic paraplegia 21 autosomal recessive Mast syndrome protein protein, BM-019 protein, SPG21.|
Coomassie Blue stained SDS-PAGE of SPG21 protein (His tag) (80R-1128)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-308 amino acids: MGSSHHHHHH SSGLVPRGSH MGEIKVSPDY NWFRGTVPLK KIIVDDDDSK IWSLYDAGPR SIRCPLIFLP PVSGTADVFF RQILALTGWG YRVIALQYPV YWDHLEFCDG FRKLLDHLQL DKVHLFGASL GGFLAQKFAE YTHKSPRVHS LILCNSFSDT SIFNQTWTAN SFWLMPAFML KKIVLGNFSS GPVDPMMADA IDFMVDRLES LGQSELASRL TLNCQNSYVE PHKIRDIPVT IMDVFDQSAL STEAKEEMYK LYPNARRAHL KTGGNFPYLC RSAEVNLYVQ IHLLQFHGTK YAAIDPSMVS AEELEVQKGS LGISQEEQ|
|Purity||> 95% pure|
|Molecular Weight||37.1 kDa (328aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Endotoxin Levels||< 1.0 EU per ug of protein (determined by LAL method)|
|Biological Significance||Spastic paraplegia 21(SPG21), also known as Maspardin, binds to the hydrophobic C-terminal amino acids of CD4 and may play a role as a negative regulatory factor in CD4-dependent T-cell activation. This protein is widely expressed in various tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Mutations in SPG21 cause Mast syndrome, an autosomal-recessive complicated form of hereditary spastic paraplegia characterized by dementia, thin corpus callosum and white matter abnormalities. Recombinant human SPG21 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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