SSB protein (GST tag) (80-1376)

Purified recombinant SSB (La) protein (GST tag)

Synonyms Sjogren Syndrome Antigen B, SS-B protein, La protein, Sjogren Syndrome B protein, Autoantigen La
Species Human
Protein Type Recombinant

Images

SDS-PAGE analysis of SSB protein (GST tag) (80-1376)

Specifications

Residues 1-408 aa
Expression System Baculovirus
Purity > 85% pure
Method of Purification Purified using proprietary chromatographic techniques
Molecular Weight 77 kDa
Tag/Conjugate GST tag
Form & Buffer Supplied in 50mM Tris buffer, pH 8.0, 100mM NaCl, 1mM EDTA, 10% glycerol and 2mM DTT

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -70 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance SSB is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus.
Expression SSB is expressed in the presence of proteins involved in DNA metabolism such as DnaG, HolC, PriA, PriB, RecO, RecQ and SbcB. Cellular localization is exclusively in the nucleus.
Implications in Disease Defects in SSB expression have been linked to instances of Sjögren's syndrome, a chronic autoimmune disease in which the body's white blood cells destroy the exocrine glands, specifically the salivary and lacrimal glands, that produce saliva and tears, respectively. SSB antibodies are also detected during Hepatitis C infection.
Post-Translational Modifications SSB is phosphorylated at the C-terminal part of the protein. Ubiquitination occurs at Lys9, Lys76, Lys95, Lys116, Lys176, Lys224, Lys229, Lys287, Lys312 and Lys328.
Database Links Entrez Gene: 6741 Human, Omim: 109090 Human, SwissProt: P05455 Human, Unigene: 632535 Human

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Images

  • SDS-PAGE analysis of SSB protein (GST tag) (80-1376)

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