STAT2 antibody (20R-2914)

Rabbit polyclonal STAT2 antibody

Synonyms Polyclonal STAT2 antibody, Anti-STAT2 antibody, STAT2 antibody, signal transducer and activator of transcription 2 antibody, 113kDa antibody, AGAP000099-PA antibody, BOS_5470 antibody, EGK_03803 antibody, ENSANGG00000006157 antibody, interferon alpha induced transcriptional activator antibody, isgf-3 antibody, P113 antibody, signal transducer and activator of transcription 2 antibody, STAT113 antibody
Cross Reactivity Human
Applications WB
Immunogen STAT2 antibody was raised in Rabbit using a synthetic target peptide as the immunogen

Images

Western Blot analysis using STAT2 antibody (20R-2914)

Specifications

Host Rabbit
Isotype IgG
Method of Purification STAT2 antibody was purified by Protein A affinity chromatography
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:2000

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance STAT2 (Signal transducer and activator of transcription 2), 113 kDa, is a member of the STAT family of cytoplasmic transcription factors. STAT members generally mediate cytokine, growth factor and hormone receptor signal transduction. STAT2 is a transcription factor critical to the signal transduction pathway of type I interferons (e.g. IFNalpha). STAT2 resides primarily in the cytoplasm and is tyrosine-phosphorylated after IFNalpha binds to cell surface receptors. In response to tyrosine phosphorylation STAT2 rapidly localizes to the nucleus and acquires the ability to bind specific DNA targets in association with two other proteins, STAT1 and IFN regulatory factor-9 (IRF-9). STAT2 is phosphorylated at Y689 by receptor-associated Janus kinasses (JAKs) leading to STAT2 dimerization and subsequent translocation to the nucleus to activate gene transcription.

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Images

  • Western Blot analysis using STAT2 antibody (20R-2914) |

Availability: In stock

Price: $295.00
Size: 100 ul
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