STAT3 antibody (10R-2073)

Mouse monoclonal STAT3 antibody

Synonyms Monoclonal STAT3 antibody, Anti-STAT3 antibody, MGC16063 antibody, STAT 3, STAT3, Signal transducer and activator of transcription 3 antibody, STAT-3 antibody, APRF antibody, STAT-3, STAT 3 antibody, FLJ20882 antibody
Cross Reactivity Human
Applications ELISA, WB
Immunogen STAT3 antibody was raised in Mouse using a purified recombinant fragment of STAT3 expressed in E. coli as the immunogen.

Images

Immunohistochemical staining using STAT3 antibody (10R-2073)

Immunohistochemical analysis of paraffin-embedded human Liver tissues using STAT3 antibody

Specifications

Host Mouse
Clone 7G3H4
Isotype IgG1
Form & Buffer Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.
Concentration 1.0 mg/ml

Usage & Assay Information

Usage Recommendations ELISA: 1:10,000, WB: 1:500-1:2000

Storage & Safety

Storage Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

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Images

  • Immunohistochemical staining using STAT3 antibody (10R-2073) | Immunohistochemical analysis of paraffin-embedded human Liver tissues using STAT3 antibody
  • Western Blot analysis using STAT3 antibody (10R-2073) | Western Blot showing STAT3 antibody used against full-length STAT3-His recombinant protein (1).

Availability: In stock

Price: $345.00
Size: 100 ul
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