STAT3 antibody (70R-14315)

Affinity purified Rabbit polyclonal STAT3 antibody

Synonyms Polyclonal STAT3 antibody, Anti-STAT3 antibody, APRF antibody, MGC16063 antibody, STAT-3, STAT-3 antibody, STAT 3, FLJ20882 antibody, STAT3, Signal transducer and activator of transcription 3 antibody, STAT 3 antibody
Applications ICC, IHC-P, WB
Immunogen STAT3 antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence at the C-terminal of human Stat3, different from the related rat and Rabbit sequences by one amino acid, as the immunogen

Images

Immunohistochemical staining using STAT3 antibody (70R-14315)

Immunohistochemistry of paraffin-embedded section of Human Lung Cancer Tissue

Specifications

Host Rabbit
Isotype IgG
Method of Purification STAT3 antibody was purified by affinity chromatography
Form & Buffer Supplied in lyophilized form

Usage & Assay Information

Usage Recommendations Optimal conditions to be determined by the end user

Storage & Safety

Storage Store at 4 deg C for short term storage. For long term storage aliquot and store at -20 deg C, avoid repeated freeze/thaw cycles.

General Information

Biological Significance STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

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Images

  • <div><font face=Calibri size=2>Immunohistochemical staining using STAT3 antibody (70R-14315)</font></div>     | Immunohistochemistry of paraffin-embedded section of Human Lung Cancer Tissue
  • <div><font face=Calibri size=2>Western Blot analysis using STAT3 antibody (70R-14315)</font></div>     | Lane 1:Rat Liver Tissue Lysate; Lane 2:Rat Brain Tissue Lysate; Lane 3:Jurkat Cell Lysate; Lane 4:SMMC Cell Lysate; Lane 5:MCF-7 Cell Lysate; Lane 6:Hela Cell Lysate

Availability: In stock

Price: $270.00
Size: 100 ug
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