STAT5a antibody (20R-2916)

Rabbit polyclonal STAT5a antibody

Synonyms Polyclonal STAT5a antibody, Anti-STAT5a antibody, STAT5A antibody, signal transducer and activator of transcription 5A antibody, BOS_19069 antibody, mammary gland factor antibody, mammary gland factor STAT5A antibody, MGF antibody, RP23-279L23.4 antibody, signal transducer and activator of transcription 5 antibody, STAT5 antibody, STAT5A antibody, Mammary Gland Factor antibody, STAT5A/MGF antibody, STATA5 antibody
Cross Reactivity Human, Mouse, Rat
Applications WB
Immunogen STAT5a antibody was raised in Rabbit using a synthetic target peptide as the immunogen

Images

Western Blot analysis using STAT5a antibody (20R-2916)

Specifications

Host Rabbit
Isotype IgG
Method of Purification STAT5a antibody was purified by Protein A affinity chromatography
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:20000

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance Signal transducer and activator of transcription (STAT), named after their dual role, generally mediate cytokine, growth factor and hormone receptor signal transduction. In mammals, seven STAT proteins have been identified. STAT5 has been implicated in cellular functions of proliferation, differentiation and apoptosis with relevance to processes of hematopoiesis and immunoregulation, reproduction, and lipid metabolism. Two highly homologous STAT5 isoforms, 96 kDa STAT5a and 94 kDa STAT5b, are encoded by two tandemly linked genes. Although both STAT5 isoforms are roughly 95% homologous at the level of cDNA, they exhibit both redundant and non-redundant functions in vivo, probably due to differences in their transactivation domain. Aberrant regulation of STAT5 has been observed in solid tumors as well as in patients with either chronic or acute myeloid leukemia. Kinase inhibitors are currently being developed to negatively regulate STAT5 activity for clinical purposes.

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Images

  • Western Blot analysis using STAT5a antibody (20R-2916) |

Availability: In stock

Price: $295.00
Size: 100 ul
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