STAT6 antibody (10R-3084)
Mouse monoclonal STAT6 antibody
|Synonyms||Monoclonal STAT6 antibody, Anti-STAT6 antibody, STAT 6, STAT-6 antibody, D12S1644 antibody, STAT 6 antibody, IL-4-STAT antibody, STAT6B antibody, STAT6C antibody, STAT6, STAT-6, Signal transducer and activator of transcription 6 antibody|
Western Blot analysis using STAT6 antibody (10R-3084)
STAT6 antibody (10R-3084) used at 1 ug/ml to detect target protein.
|Form & Buffer||Supplied in lyophilized form with PBS buffer. Reconstitute in 100 ul of distilled water.|
Usage & Assay Information
|Usage Recommendations||WB: 1.0 ug/ml|
Storage & Safety
|Storage||Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze-thaw cycles.|
|Biological Significance||STAT6 is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins.|
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