Stathmin protein (His tag) (80R-1123)
Purified recombinant Human Stathmin protein
|Synonyms||OP 18 protein, LAP18 protein, Stathmin1 protein, Oncoprotein 18(Op18) protein, Stathmin protein, OP18 protein, Protein Pr22 protein, pp17 protein, Lag protein, Oncoprotein 18 protein, Metablastin protein, Prosolin protein, Phosphoprotein p19 (pp19) protein, p18 protein, LAP 18 protein, Metablastin protein, Phosphoprotein 19 protein, Phosphoprotein p19 protein, Prosolin protein, PR22 protein, Leukemia associated phosphoprotein p18 protein, STMN 1., SMN protein, Pr22 protein protein, STMN1 protein, p19 protein, PP19 protein|
Coomassie Blue stained SDS-PAGE of Stathmin protein (His tag) (80R-1123)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-149 amino acids: MGSSHHHHHH SSGLVPRGSH MASSDIQVKE LEKRASGQAF ELILSPRSKE SVPEFPLSPP KKKDLSLEEI QKKLEAAEER RKSHEAEVLK QLAEKREHEK EVLQKAIEEN NNFSKMAEEK LTHKMEANKE NREAQMAAKL ERLREKDKHI EEVRKNKESK DPADETEAD|
|Purity||> 95% pure|
|Molecular Weight||19.4 kDa (169aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Stathmin is a ubiquitous phosphoprotein proposed to play a general role as an intracellular relay integrating diverse regulatory signals of the cellular environment. Also, Stathmin protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. The role of Stathmin in regulation of the cell cycle causes it to be an oncoprotein (Oncoprotein 18, op18). When Stathmin is mutated and not functioning properly, this protein can cause uncontrolled cell proliferation. Recombinant human Stathmin protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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