TARDBP protein (His tag) (80R-2736)

Purified recombinant TARDBP protein (His tag)

Synonyms TAR DNA binding protein protein, ALS10 protein, TDP43 protein, TARDBP
Species Human
Protein Type Recombinant
Applications SDS-PAGE

Specifications

Residues 1-260 aa: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMSEY IRVTEDENDE PIEIPSEDDG TVLLSTVTAQ FPGACGLRYR NPVSQCMRGV RLVEGILHAP DAGWGNLVYV VNYPKDNKRK MDETDASSAV KVKRAVQKTS DLIVLGLPWK TTEQDLKEYF STFGEVLMVQ VKKDLKTGHS KGFGFVRFTE YETQVKVMSQ RHMIDGRWCD CKLPNSKQSQ DEPLRSRKVF VGRCTEDMTE DELREFFSQY GDVMDVFIPK PFRAFAFVTF ADDQIAQSLC GEDLIIKGIS VHISNA
Expression System E.coli
Purity > 90% pure
Molecular Weight 33.6 kDa
Tag/Conjugate His tag
Form & Buffer Supplied in liquid form in 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol 0.1M NaCl
Concentration 500 ug/ml

Storage & Safety

Storage Can be stored at 4 deg C for short terms (1-2 weeks). For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freezing and thawing cycles

General Information

Biological Significance TARDBP was originally identified as a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. It has also been identified in individuals diagnosed with chronic traumatic encephalopathy, a condition that often mimics ALS and that has been associated with athletes who have experienced multiple concussions and other types of head injury. It has been shown to bind both DNA and RNA and have multiple functions in transcriptional repression, pre-mRNA splicing and translational regulation. Recombinant human TARDBP protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques

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Availability: In stock

Price: $270.00
Size: 20 ug
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