TCPTP antibody (10R-8623)

Mouse monoclonal TCPTP antibody

Synonyms Monoclonal TCPTP antibody, Anti-TCPTP antibody, PTPN2 antibody, protein tyrosine phosphatase antibody, non-receptor type 2 antibody, BOS_22287 antibody, MPTP antibody, phosphoprotein phosphatase antibody, protein-tyrosine phosphatase PTP-2 antibody, protein-tyrosine phosphatase PTP-S antibody, ptn2 antibody, Ptpt antibody, T cell protein-tyrosine phosphatase antibody, T-cell protein tyrosine phosphatase antibody, TCELLPTP antibody, TCPTP antibody, TC-PTP antibody, tyrosine-protein phosphatase non-receptor type 2 antibody
Cross Reactivity Human
Applications ELISA, WB
Immunogen TCPTP antibody was raised in Mouse using a recombinant human protein purified from E.coli as the immunogen

Images

Western Blot analysis using TCPTP antibody (10R-8623)

Specifications

Host Mouse
Clone T25-AF3B7
Isotype IgG2b kappa
Method of Purification TCPTP antibody was purified by ammonium sulfate precipitation
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:2000

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance T cell protein tyrosine phosphatase (TCPTP), also known as PTPT and PTPN2, is an enzyme that removes phosphate groups covalently attached to tyrosine residues in proteins. TCPTP is ubiquitously expressed with particularly high expression in hematopoietic tissues and exists as two forms: an endoplasmic reticulum-targeted 48- kDa form (TC48) and a nuclear 45- kDa form (TC45). Although targeted to the nucleus, TC45 can exit in response to specific stimuli to dephosphorylate cytoplasmic substrates. TC-PTP is a negative regulator of the Jak/Stat cytokine signaling pathway. TCPTP is the PTP most closely related to PTP1B, with 72% sequence identity and 86% similarity in the catalytic domain.

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Images

  • Western Blot analysis using TCPTP antibody (10R-8623) |

Availability: In stock

Price: $295.00
Size: 100 ul
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