TEF protein (His tag) (80R-2875)
Purified recombinant TEF protein (His tag)
|Synonyms||Thyrotroph embryonic factor isoform 1 protein, KIAA1655 protein, Thyrotroph embryonic factor protein, TEF|
SDS-PAGE analysis of TEF protein (His tag) (80R-2875)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-303 aa: MGSSHHHHHH SSGLVPRGSH MGSMSDAGGG KKPPVDPQAG PGPGPGRAAG ERGLSGSFPL VLKKLMENPP REARLDKEKG KEKLEEDEAA AASTMAVSAS LMPPIWDKTI PYDGESFHLE YMDLDEFLLE NGIPASPTHL AHNLLLPVAE LEGKESASSS TASPPSSSTA IFQPSETVSS TESSLEKERE TPSPIDPNCV EVDVNFNPDP ADLVLSSVPG GELFNPRKHK FAEEDLKPQP MIKKAKKVFV PDEQKDEKYW TRRKKNNVAA KRSRDARRLK ENQITIRAAF LEKENTALRT EVAELRKEVG KCKTIVSKYE TKYGPL|
|Purity||> 85% pure|
|Molecular Weight||35.6 kDa|
|Form & Buffer||Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol|
Storage & Safety
|Storage||Can be stored at 4 deg C short term (1-2 weeks). For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freezing and thawing cycles.|
|Biological Significance||Thyrotroph embryonic factor isoform 1, also known as TEF, is a 303 amino acid nuclear transcription factor that belongs to the bZIP (basic region/leucine zipper) family and PAR (proline and acidic amino acid-rich) subfamily. TEF binds DNA as either a homodimer or heterodimer, and is known to transactivate the TSH beta promoter. TEF accumulates according to a robust circadian rhythm and has also been found to inhibit cell growth by down-regulating beta chain expression of cytokine receptors.|
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