TEN1 protein (His tag) (80R-2871)
Purified recombinant TEN1 protein (His tag)
|Synonyms||CST complex subunit TEN1 protein, TEN1 telomerase capping complex subunit homolog protein, C17orf106 protein, TEN1|
SDS-PAGE analysis of TEN1 protein (His tag) (80R-2871)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-123 aa: MGSSHHHHHH SSGLVPRGSH MGSMMLPKPG TYYLPWEVSA GQVPDGSTLR TFGRLCLYDM IQSRVTLMAQ HGSDQHQVLV CTKLVEPFHA QVGSLYIVLG ELQHQQDRGS VVKARVLTCV EGMNLPLLEQ AIREQRLYKQ ERGGSQ|
|Purity||> 90% pure|
|Molecular Weight||16.2 kDa|
|Form & Buffer||Supplied in liquid form in 20mM Tris-HCl buffer (pH 7.5) containing 0.15M NaCl, 10% glycerol, 1mM DTT|
Storage & Safety
|Storage||Can be stored at 4 deg C short term (1-2 weeks). For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freezing and thawing cycles.|
|Biological Significance||TEN1 is component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.|
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