TFEB antibody (10R-1611)

Mouse monoclonal TFEB antibody

Synonyms Monoclonal TFEB antibody, Anti-TFEB antibody, Transcription factor EB antibody, AlphaT antibody, AlphaT antibody, TCFEB antibody, Transcription factor EB antibody, Anti TFEB antibody, TFEB antibody, TCFEB antibody
Specificity Human TFEB
Cross Reactivity Human. Other species not studied
Applications Dot Blot, WB
Immunogen TFEB antibody was raised in mouse using recombinant Human Transcription Factor Eb (Tfeb)

Images

Western Blot analysis of immunized recombinant protein using TFEB antibody (10R-1611)

Left: RUNX3 staining. Right: Coomassie Blue staining of immunized recombinant protein.

Specifications

Host Mouse
Clone 319C2a
Isotype IgG1
Method of Purification TFEB antibody was purified using protein G column chromatography from culture supernatant of hybridomacultured in a medium containing bovine IgG-depleted(approximately 95%) fetal bovine serum.
Form & Buffer TFEB antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3 ).
Concentration 100 ug/ml

Usage & Assay Information

Usage Recommendations To be optimized by the end user.

Storage & Safety

Storage Store at 2-8 deg C for up to one year. We recommend long term storage at -20 deg C. Avoid repeated freezing and thawing.
Biohazard Information This antibody solution contains sodium azide (NaN ) as a preservative. There is a potential hazard that NaN reacts with copper or lead to produce an explosive compound. For safe disposal, the vial has to be washed thoroughly with water. It is strongly adv

General Information

Biological Significance Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.

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Images

  • Western Blot analysis of immunized recombinant protein using TFEB antibody (10R-1611) | Left: RUNX3 staining. Right: Coomassie Blue staining of immunized recombinant protein.

Availability: In stock

Price: $190.00
Size: 50 ug
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