TG3 protein (His tag) (80-1386)

Purified recombinant Transglutaminase 3 (TG3) protein (His tag)

Synonyms Transglutaminase 3 protein, TG3 protein, TG(E) protein, TGase-3 protein, Protein-glutamine-gamma-glutamyltransferase protein
Species Human
Protein Type Recombinant

Specifications

Residues 1-693 aa
Expression System Baculovirus
Purity > 90% pure
Method of Purification Purified using proprietary chromatographic techniques
Molecular Weight 79 kDa
Tag/Conjugate His tag
Form & Buffer Supplied in 50mM Na2PO4 pH 8.0, 150mM NaCl, 10% glycerol, 2mM DTT and 1mM EDTA

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -70 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance TG3 catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins.
Expression Expression levels are increased in relation to calcium ion concentration. Tissue and Cell Localization: TG3 proteins are widely distributed in the cytoplasm.
Implications in Disease Anti-transglutaminase antibodies are found in celiac disease and may play a role in the small bowel damage in response to dietary gliadin that characterises this condition.
Post-Translational Modifications TG3 is activated by proteolytic processing. In vitro activation is commonly achieved by cleavage with dispase, a neutral bacterial protease. Dispase cleavage site was proposed to lie between Ser-470 and Ser-471.
Database Links Entrez Gene: 7053 Human, Omim: 600238 Human, SwissProt: Q08188 Human, Unigene: 2022 Human

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