TGF beta 2 protein (30R-AT073)

Purified recombinant Human TGF beta 2 protein

Synonyms Glioblastoma-derived T cell suppressor factor protein, TGF beta 2 protein, TGFB2 protein, TGF beta-2 protein, BSC-1 protein, Transforming Growth Factor-beta2 protein, Polyergin protein, TGF beta-2, Cetermin protein, TGF beta-2 protein, TGF beta 2, TGF beta 2, TGF-2b protein
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of TGF beta 2 protein corresponding to amino acids ALDAAYCFRN VQDNCCLRPL YIDFKRDLGW KWIHEPKGYN ANFCAGACPY LWSSDTQHSR VLSLYNTINP EASASPCCVS QDLEPLTILY YIGKTPKIEQ LSNMIVKSCK CS.
Expression System 293 cells
Purity > 98% pure
Form & Buffer Supplied as a lyophilized powder.

Usage & Assay Information

Bioactivity Determined by its ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells. The ED50 was found to be approximately 0.2 ng/ml, corresponding to a specific activity of approximately 5 x 10^6 units/mg.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance The three mammalian isoforms of TGF beta, TGF beta1, beta2, beta3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF beta isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1.

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Availability: In stock

Price: $225.00
Size: 10 ug
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