THOC1 antibody (10R-1501)

Mouse monoclonal THOC1 antibody

Synonyms Monoclonal THOC1 antibody, Anti-THOC1 antibody, HPR1 antibody, THOC1, THO 1c, THO-1c, P84N5 antibody, P84 antibody, THO-1c antibody, THO complex 1 antibody, THO 1c antibody
Specificity Human THOC1
Cross Reactivity Human. Other species not studied
Applications Dot Blot
Immunogen THOC1 antibody was raised in mouse using recombinant Human Tho Complex 1

Images

Western Blot analysis of immunized recombinant protein using THOC1 antibody (10R-1501)

Specifications

Host Mouse
Clone 3121C2a
Isotype IgG2b
Method of Purification THOC1 antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Form & Buffer THOC1 antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3 ).
Concentration 100 ug/ml

Usage & Assay Information

Usage Recommendations To be optimized by the end user.

Storage & Safety

Storage Store at 2-8 deg C for up to one year. We recommend long term storage at -20 deg C. Avoid repeated freezing and thawing.
Biohazard Information This antibody solution contains sodium azide (NaN ) as a preservative. There is a potential hazard that NaN reacts with copper or lead to produce an explosive compound. For safe disposal, the vial has to be washed thoroughly with water. It is strongly adv

General Information

Biological Significance THOC1 is a component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between THOC4 and the cap-binding protein NCBP1. UAP56 functions as a bridge between THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.

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Images

  • Western Blot analysis of immunized recombinant protein using THOC1 antibody (10R-1501)

Availability: In stock

Price: $190.00
Size: 50 ug
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