Thomsen-Friedenreich antibody (10R-T110a)

Mouse monoclonal Thomsen-Friedenreich antibody

Synonyms Monoclonal Thomsen-Friedenreich antibody, Anti-Thomsen-Friedenreich antibody
Specificity Human
Cross Reactivity Rat
Applications IF, IHC-F, IHC-P
Immunogen Thomsen-Friedenreich antibody was raised in mouse using neuraminidase-treated human red blood cells as the immunogen.

Images

Immunohistochemical staining using Thomsen-Friedenreich antibody (10R-T110a)

Formalin-fixed, paraffin-embedded human colon adenocarcinoma stained with Thomsen-Friedenreich Antigen antibody using peroxidase-conjugate and DAB chromogen. Note cell membrane staining of tumor cells.

Specifications

Host Mouse
Clone A78-G/A7
Isotype IgM
Method of Purification Thomsen-Friedenreich antibody was purified by Ammonium sulfate precipitation.
Form & Buffer 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% NaN3.
Concentration 0.2 mg/ml

Usage & Assay Information

Usage Recommendations IHC-F: 1:25-1:50, IHC-P: 1:25-1:50

Storage & Safety

Storage Store at 4 deg C.
Biohazard Information This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling.

General Information

Biological Significance The Thomsen-Friedenreich antigen acts as an oncofetal antigen, with low expression in normal adult tissues but increasing to fetal levels of expression in hyperplasia or malignancy. It is considered as a pan-carcinoma marker. Expression is on the apical surface of mucin-producing normal and cancerous colorectal epithelial cells. Staining is also present in the secreted mucin.

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Images

  • Immunohistochemical staining using Thomsen-Friedenreich antibody (10R-T110a) | Formalin-fixed, paraffin-embedded human colon adenocarcinoma stained with Thomsen-Friedenreich Antigen antibody using peroxidase-conjugate and DAB chromogen. Note cell membrane staining of tumor cells.

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Price: $405.00
Size: 100 ug
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