TIMP1 protein (30R-AT082)

Purified recombinant Human TIMP1 protein

Synonyms TIMP 1 protein, TIMP-1 protein, TIMP-1, Tissue inhibitor of metalloproteinases: Fibroblast collagenase inhibitor; Erythroid-potentiating activity protein, TIMP1, TIMP 1, TIMP-1 protein
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of TIMP1 protein corresponding to amino acids CTCVPPHPQT AFCNSDLVIR AKFVGTPEVN QTTLYQRYEI KMTKMYKGFQ ALGDAADIRF VYTPAMESVC GYFHRSHNRS EEFLIAGKLQ DGLLHITTCS FVAPWNSLSL AQRRGFTKTY TVGCEECTVF PCLSIPCKLQ SGTHCLWTDQ LLQGSEKGFQ SRHLACLPRE PGLCTWQSLR SQIA.
Expression System E.coli
Purity > 95% pure
Molecular Weight 20.6 kDa
Form & Buffer Supplied as a lyophilized powder.

Usage & Assay Information

Bioactivity TIMP1 activity was measured by its ability to inhibit human MMP-1 induced hydrolysis of a chromogenic peptide substrate at room temperature. Half maximal inhibition was obtained at a TIMP-1 concentration of approximately 0.5 ug/ml, when using an MMP-1 con

Storage & Safety

Storage Ships ambient or refrigerated. Upon receipt store the lyophilized protein at -20 deg C. Working aliquots stored with a carrier protein are stable for 3 months at -20 deg C
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance TIMP1 is an extracellular inhibitor of MMPs (see above) including MMP1, 2, 3, 7, 8, 9, 10, 11, 12, 13, and 16. It belongs to the I35 (TIMP) family of irreversible protease inhibitors that function as key modulators of extracellular matrix degradation during tissue development and remodeling. TIMP1 can also act through an MMP-independent mechanism to promote erythropoiesis by stimulating proliferation and differentiation of erythroid progenitors.

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Availability: In stock

Price: $225.00
Size: 10 ug
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