TL1A protein (30R-AT070)

Purified recombinant Human TL1A protein

Synonyms VEGI protein, TNFSF15 protein, TL-1A protein, TLA 1, TL1A, TLA 1 protein, TLA-1, TLA-1 protein
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of TL1A protein corresponding to amino acids QLRAQGEASV QFQALKGQEF APSHQQVYAP LRADGDKPRA HLTVVRQTPT QHFKNQFPAL HWEHELGLAF TKNRMNYTNK FLLIPESGDY FIYSQVTFRG MTSECSEIRQ AGRPNKPDSI TVVITKVTDS YPEPTQLLMG TKSVCEVGSN WFQPIYLGAM FSLQEGDKLM VNVSDISLVD YTKEDKTFFG AFLL.
Expression System E.coli
Purity > 98% pure
Molecular Weight 22.0 kDa
Form & Buffer Supplied as a lyophilized powder.

Usage & Assay Information

Bioactivity Determined by its ability to stimulate IFN-gamma production by human PBMC using a concentration range of 10.0-100.0 ng/ml. Note: Results may vary with PBMC donors.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance TL-1A belongs to the TNF superfamily of ligands. It is expressed predominantly in endothelial cells, and to a lesser extent in placenta, lung, kidney, skeletal muscle, pancreas, small intestine and colon. TL-1A inhibits endothelial cell proliferation and angiogenesis, and has been shown to induce NF kb activation, caspase activity, and apoptosis in responding cell lines. TL-1A interacts with TNFRSF25/DR3 receptor, but can also bind to a decoy receptor TNFRSF21/DR6.

References
Add a Paper

Thomas LS, Targan SR, Tsuda M, Yu QT, Salumbides BC, Haritunians T, Mengesha E, McGovern DP, Michelsen KS

The TNF family member TL1A induces IL-22 secretion in committed human Th17 cells via IL-9 induction

J Leukoc Biol.

PMID: 27733581 DOI: 10.1189/jlb.3A0316-129R

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Availability: In stock

Price: $225.00
Size: 20 ug
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