TMED10 protein (His tag) (80R-2959)
Purified recombinant CTSF protein (His tag)
|Synonyms||Transmembrane emp24 domain-containing 10 protein, p23 protein, P24(DELTA) protein, S31I125 protein, S31III125 protein, Tmp-21-I protein, TMP21 protein|
SDS-PAGE analysis of TMED10 protein (His Tag) (80R-2959)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||32-185 aa: MGSSHHHHHH SSGLVPRGSH MGSISFHLPI NSRKCLREEI HKDLLVTGAY EISDQSGGAG GLRSHLKITD SAGHILYSKE DATKGKFAFT TEDYDMFEVC FESKGTGRIP DQLVILDMKH GVEAKNYEEI AKVEKLKPLE VELRRLEDLS ESIVNDFAYM KKREEEMRDT NESTNTR|
|Purity||> 85% pure|
|Molecular Weight||20 kDa|
|Form & Buffer||Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 30% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for up to 2 weeks. For long term storage, aliquot and store at -20 deg C to -70 deg C. Avoid repeated freeze/thaw cycles|
|Biological Significance||TMED10 is a member of the EMP24/GP25L/p24 family and a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8.|
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