TNF Receptor Type I protein (30R-AT056)

Purified recombinant Human TNF Receptor Type I protein

Synonyms TNFR60 protein, TNF-R55 protein, TNF Receptor 1 protein, TNF Receptor I protein, CD120a protein, TNFRSF1A protein, p55 protein, TNFAR protein, Soluble Tumor Necrosis Factor type I protein
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of TNF Receptor Type I protein corresponding to amino acids MDSVCPQGKY IHPQNNSICC TKCHKGTYLY NDCPGPGQDT DCRECESGSF TASENHLRHC LSCSKCRKEM GQVEISSCTV DRDTVCGCRK NQYRHYWSEN LFQCFNCSLC LNGTVHLSCQ EKQNTVCTCH AGFFLRENEC VSCSNCKKSL ECTKLCLPQI EN
Expression System E.coli
Purity > 97% pure
Molecular Weight 18.3 kDa
Form & Buffer Supplied as a lyophilized powder.

Usage & Assay Information

Bioactivity Determined by its inhibitory effect of the TNF-alpha mediated cytotoxicity in Mouse L-929 cells. The ED50 for this effect in the presence of 0.25 ng/ml of recombinant human TNF-alpha, is 0.05 ug/ml.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance TNFR1 belongs to the TNFR superfamily of transmembrane proteins, and is expressed in most cell types. Binding of either TNF-alpha or TNF-beta to TNFR1 initiates a signal transduction pathway that results in the activation of the transduction factor NF kb, whose target genes are involved in the regulation of inflammatory responses, and, in certain cells induce apoptosis. Soluble TNF Receptor I (sTNFR1) is capable of inhibiting TNF-alpha and TNF-beta activities by acting as a decoy receptor that serves as a sink for the TNF ligands.

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Availability: In stock

Price: $225.00
Size: 20 ug
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