TNFa protein (30R-2148)
Purified recombinant Mouse TNFa Protein
|Synonyms||Tumor necrosis factor protein, Cachectin protein, TNFalpha protein, TNFSF2 protein, Tnfsf1a protein, DIF protein, TNF-alpha protein|
Coomassie Blue stained SDS-PAGE of TNFa protein (30R-2148)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||MLRSSSQNSS DKPVAHVVAN HQVEEQLEWL SQRANALLAN GMDLKDNQLV VPADGLYLVY SQVLFKGQGC PDYVLLTHTV SRFAISYQEK VNLLSAVKSP CPKDTPEGAE LKPWYEPIYL GGVFQLEKGD QLSAEVNLPK YLDFAESGQV YFGVIAL|
|Purity||> 95% pure|
|Molecular Weight||17.4 kDa|
|Form & Buffer||Supplied in liquid form in Phosphate buffered saline, pH 7.4.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||TNFa is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.|
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