TNFAIP8 protein (His tag) (80R-2855)
Purified recombinant TNFAIP8 protein (His tag)
|Synonyms||TNFAIP8, TNFAIP 8, TNFAIP-8, TNFAIP8, TNFAIP 8 protein, TNFAIP-8 protein, Tumor necrosis factor alpha-induced 8 protein, GG2-1 protein, MDC-3.13 protein, SCC-S2 protein, SCCS2 protein|
SDS-PAGE analysis of TNFAIP8 protein (His tag) (80R-2855)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-198 aa: MGSSHHHHHH SSGLVPRGSH MGSMHSEAEE SKEVATDVFN SKNLAVQAQK KILGKMVSKS IATTLIDDTS SEVLDELYRV TREYTQNKKE AEKIIKNLIK TVIKLAILYR NNQFNQDELA LMEKFKKKVH QLAMTVVSFH QVDYTFDRNV LSRLLNECRE MLHQIIQRHL TAKSHGRVNN VFDHFSDCEF LAALYNPFGN FKPHLQKLCD GINKMLDEEN I|
|Purity||> 90% pure|
|Molecular Weight||25 kDa|
|Form & Buffer||Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT|
Storage & Safety
|Storage||Can be stored at 4 deg C short term (1-2 weeks). For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freezing and thawing cycles.|
|Biological Significance||TNFAIP8 belongs to the TNFAIP8 family. This protein acts as a negative mediator of apoptosis and may play a role in tumor progression. It suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation. Recombinant human TNFAIP8 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
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