TP53AIP1 protein (His tag) (80R-2984)
Purified recombinant TP53AIP1 protein (His tag)
|Synonyms||P53-regulated apoptosis-inducing 1 isoform a protein, TPIP1 protein, P53AIP1 protein, TP53AIP 1 protein, TP53AIP-1 protein|
SDS-PAGE analysis of TP53AIP1 protein (His tag) (80R-2984)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-124 aa: MGSSHHHHHH SSGLVPRGSH MGSSSEASFR SAQASCSGAR RQGLGRGDQN LSVMPPNGRA QTHTPGWVSD PLVLGAQVHG GCRGIEALSV SSGSWSSATV WILTGLGLGL SRPFLPGATV LRDRPLGSAF ELSYDQKKAP LRLQ|
|Form & Buffer||Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M Urea|
Storage & Safety
|Storage||Store at 4 deg C for short term storage, for long term storage aliquot and store at -20 deg C or -70 deg C, avoid repeated freeze thaw cycles.|
|Biological Significance||PPM1F is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase.|
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