TPM1 protein (His tag) (80R-1445)
Purified recombinant Human TPM1 protein
|Synonyms||TPM-1 protein, TPM1, TMSA protein, Alpha-tropomyosin protein, TPM1 protein, HTM-alpha protein, Tropomyosin alpha-1 chain, TPM 1 protein, Tropomyosin-1 protein, CMD1Y protein, TPM-1, TPM 1|
Coomassie Blue stained SDS-PAGE of TPM1 protein (His tag) (80R-1445)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-284 amino acids: MGSSHHHHHH SSGLVPRGSH MDAIKKKMQM LKLDKENALD RAEQAEADKK AAEDRSKQLE DELVSLQKKL KGTEDELDKY SEALKDAQEK LELAEKKATD AEADVASLNR RIQLVEEELD RAQERLATAL QKLEEAEKAA DESERGMKVI ESRAQKDEEK MEIQEIQLKE AKHIAEDADR KYEEVARKLV IIESDLERAE ERAELSEGQV RQLEEQLRIM DQTLKALMAA EDKYSQKEDR YEEEIKVLSD KLKEAETRAE FAERSVTKLE KSIDDLEDEL YAQKLKYKAI SEELDHALND MTSM|
|Purity||> 90% pure|
|Molecular Weight||35.0 kDa (304aa), confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher))|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 20% glycerol, 0.1M NaCl, and 1mM DTT.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||TPM1 is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. TPM1 is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. Recombinant human TPM1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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