TPMT antibody (10R-3130)
Mouse monoclonal NANS antibody
|Synonyms||Monoclonal NANS antibody, Anti-NANS antibody Thiopurine S-methyltransferase antibody, Thiopurine methyltransferase antibody, Thiopurine S-methyltransferase HGNC:12014 antibody, Thiopurine methyltransferase antibody, TPMT antibody, S adenosyl L methionine thiopurine S methyltransferase antibody, Thiopurine S-methyltransferase HGNC:12014 antibody, TPMT antibody, S adenosyl L methionine thiopurine S methyltransferase antibody, Thiopurine S methyltransferase antibody, NANS antibody, Thiopurine S methyltransferase antibody, Anti NANS antibody Thiopurine S-methyltransferase antibody|
|Immunogen||TPMT antibody was raised in mouse using recombinant human TPMT (1-245aa) purified from E. coli as the immunogen.|
Western Blot analysis of TPMT antibody (10R-3130)
The cell lysates (40 ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human TPMT antibody (1:1,000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
|Method of Purification||TPMT antibody was purified by protein G affinity chromatography.|
|Form & Buffer||Supplied as a liquid in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide|
Usage & Assay Information
|Usage Recommendations||WB: 1:1000|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||TPMT is a very important enzyme for the metabolizm of thiopurine compounds. TPMT pharmacogenetics has been studied extensively because of its clinical significance. Many patients got benefited from the knowledge of TPMT genotype-phenotype correlation. Also, TPMT activity exhibits autosomal codominant genetic polymorphism, and patients inheriting TPMT-deficiency are at high risk of potentially fatal hematopoietic toxicity.|
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