TRAIL protein (30R-1127)
Purified recombinant Human TRAIL protein
|Synonyms||TNFSF10 protein, TRAIL protein, Apo-2 ligand protein, TL2 protein, member 10, Tumor necrosis factor ligand superfamily protein, Tumor necrosis factor (ligand) superfamily protein, CD253 protein, member 10 protein, APO2L protein|
Coomassie Blue stained SDS-PAGE of TRAIL protein (30R-1127)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||114-281 amino acids: MVRERGPQRV AAHITGTRGR SNTLSSPNSK NEKALGRKIN SWESSRSGHS FLSNLHLRNG ELVIHEKGFY YIYSQTYFRF QEEIKENTKN DKQMVQYIYK YTSYPDPILL MKSARNSCWS KDAEYGLYSI YQGGIFELKE NDRIFVSVTN EHLIDMDHEA SFFGAFLVG|
|Purity||> 95% pure|
|Molecular Weight||23 kDa (211 aa)|
|Form & Buffer||Supplied as a liquid in 20mM Tris, pH 7.5, containing 300mM NaCl, 0.1mM DTT, and 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Endotoxin Levels||< 1.0 EU per ug of protein (determined by LAL method)|
|Biological Significance||TNF-related apoptosis-inducing ligand (TRAIL) belongs to the tumor necrosis factor (TNF) cytokine family and induces rapid apoptosis in a wide variety of tumor cell lines upon binding to the death-signalling receptors on the cell membrane. TRAIL binds to one of four receptors that have been identified in humans, including TRAIL-R1/DR4, TRAIL-R2/KILLER/DR5, TRAIL-R3/DcR1/TRID, and TRAIL-R4/DcR2/TRUNDD. Both DR4 and DR5 are pro-apoptotic receptors, which contain a cytoplasmic death domain and mediate apoptosis on binding to TRAIL. By contrast, TRID and TRUNDD do not contain a cytoplasmic death domain and block the function of TRAIL by competing with DR4 and DR5 for binding of TRAIL. Recombinant human TRAIL was expressed in E. coli and purified by using conventional chromatography techniques.|
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