Transferrin Receptor antibody (10R-8123)

Mouse monoclonal Transferrin Receptor antibody

Synonyms Monoclonal Transferrin Receptor antibody, Anti-Transferrin Receptor antibody, CD71 antibody, CD71 antigen antibody, p90 antibody, sTfR antibody, T9 antibody, TFR 1 antibody, TFR antibody TFR1 antibody, TFRC antibody, TR antibody, Transferrin receptor (p90 CD71) antibody, Transferrin Receptor Protein 1 antibody, TRFR antibody , Transferrin Receptor
Specificity Reacts with the transferrin receptor, a 180-190 kD transmembrane glycoprotein which exists as a 95 kD homodimer with interchain disulfide bond
Cross Reactivity Human
Applications FC, IHC-F, IP, WB
Immunogen Transferrin Receptor antibody was raised in Mouse using human T-cells as the immunogen.

Specifications

Host Mouse
Clone 66IG10
Isotype IgG1
Form & Buffer Supplied in PBS containing 0.09% sodium azide

Usage & Assay Information

Usage Recommendations Optimal dilution should be determined by titration

General Information

Biological Significance Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.

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Availability: In stock

Price: $395.00
Size: 100 ug
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