TREM2 protein (His tag) (80R-3585)
Purified recombinant TREM2 protein (His tag)
|Synonyms||Trem2a protein, Trem2b protein, Trem2c protein, TREM 2 protein, TREM-2 protein|
Coomassie blue stained SDS-PAGE of TREM2 protein (His tag) (80R-3585)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||19-161 aa: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMHN TTVFQGVAGQ SLQVSCPYDS MKHWGRRKAW CRQLGEKGPC QRVVSTHNLW LLSFLRRWNG STAITDDTLG GTLTITLRNL QPHDAGLYQC QSLHGSEADT LRKVLVEVLA DPLDHRDAGD LWFPGESESF EDAHVEHSIS R|
|Purity||> 90% pure|
|Method of Purification||TREM2 protein was purified by using conventional chromatography techniques|
|Molecular Weight||20.4 kDa|
|Form & Buffer||Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT|
Storage & Safety
|Storage||Can be stored at 4 deg C short term (1-2 weeks). For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freezing and thawing cycles.|
|Biological Significance||TREM2 is a membrane protein that forms a receptorsignaling complex with the TYRO protein tyrosine kinase bindingprotein. The protein functions in immune response and maybe involved in chronic inflammation by triggering the production ofconstitutive inflammatory cytokines. Defects in this gene are acause of polycystic lipomembranous osteodysplasia with sclerosingleukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms.|
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