TRIM21 protein (His tag) (80-1385)

Purified recombinant TRIM21 (Ro52) protein (His tag)

Synonyms 52 KDa Ribonucleoprotein Autoantigen Ro, Ro-52 protein, Trim21 protein, RNF81 protein, RO52 protein, SSA protein, SSA1 protein, TRIM 21 protein
Species Human
Protein Type Recombinant
Immunogen

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Specifications

Residues 1-285 aa
Expression System E.coli
Purity > 90% pure
Method of Purification Purified using proprietary chromatographic techniques
Molecular Weight 31 kDa
Tag/Conjugate His tag
Form & Buffer Supplied in 50mM Tris buffer pH 8.5, 100mM NaCl, 1mM EDTA, 2mM DTT and 0.02%SDS

Storage & Safety

Storage Ships on dry ice. Upon receipt store at -70 deg C. Avoid repeated freeze-thaw cycles.

General Information

Biological Significance TRIM21 is an intracellular antibody effector in the intracellular antibody-mediated proteolysis pathway. It binds to immunoglobulin G as well as immunoglobulin M on antibody marked non-enveloped virions which have infected the cell.
Expression As a component of the proteolysis pathway, TRIM21 is expressed in most human tissues. Tissue and Cell Localization: TRIM21 is mainly found in the cytoplasm and the nucleus. Isoform 1 and isoform 2 are expressed in fetal and adult heart and fetal lung.
Implications in Disease TRIM21 interacts with autoantigens in patients with Sjögren's syndrome and systemic lupus erythematosus.
Post-Translational Modifications TRIM21 is autoubiquitinated which does not lead to its proteasomal degradation. Deubiquitinated by USP4; leading to its stabilization. Ubiquitination occurs at Lys260.
Database Links Entrez Gene: 6737 Human, Omim: 109092 Human, SwissProt: P19474 Human, Unigene: 532357 Human

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