TRIM5 alpha antibody (10R-1789)

Mouse monoclonal TRIM5 alpha antibody

Synonyms Monoclonal TRIM5 alpha antibody, Anti-TRIM5 alpha antibody, TRIM-5 alpha antibody, TRIM-5 alpha, TRIM 5 alpha antibody, TRIM-5 alpha antibody, TRIM5 alpha, TRIM 5 alpha antibody, TRIM 5 alpha
Cross Reactivity Human
Applications ELISA, IHC, WB
Immunogen TRIM5 alpha antibody was raised in Mouse using a purified recombinant fragment of human TRIM5 alpha expressed in E. coli as the immunogen.

Specifications

Host Mouse
Clone 3B11H2
Isotype IgG1
Form & Buffer Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.
Concentration 1.0 mg/ml

Usage & Assay Information

Usage Recommendations ELISA: 1:10,000, IHC: 1:200-1:1000, WB: 1:500-1:2000

Storage & Safety

Storage Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance TRIM5 alpha is a protein that is found in the cells of many mammals and fends of various retrovirus infections. It protects monkeys from infection with HIV-1, and humans from infection with some other viruses. If a retrovirus has entered a cell, it needs to shed its capsid in order to reversely transcribe its genes, so that they can be expressed by the host cell. It is believed that TRIM5 alpha, which is present in the cytoplasm, somehow recognizes the capsid and blocks its shedding, thereby stopping the virus in its tracks. It thus represents an intracellular defense completely separate from the rest of the body's immune system.

References
Add a Paper

Sorry, but there are no references currently for this product.

Reviews

You need to be logged in to write a review. Please login here

Sorry there are currently no reviews for this product

Availability: In stock

Price: $375.00
Size: 100 ul
OR
Shipping
View Our Distributors